Cover letter 2

Dear Dr Jeffrey D. Blaustein
We are submitting our paper entitled: “Chronic intermittent prenatal stress alters sexual development in male rats” to Endocrinology Journal. The authors of this article are the following Jonathan Martínez, XX and XXN. This manuscript has been read and approved by all authors.

Several studies have shown that alterations in the gestational period, including stress may alter the normal development of a fetus, with impact in the adult life. we propose that prenatal stress may affect the correct function of the reproductive tract. The aim of this study was to evaluate the adrenal-gonadal function of prenatal stressed male rats. Our results suggest that chronic prenatal stress produces an alteration in the adrenal and vas deferens noradrenaline content that may modify the metabolic and reproductive funtion in adult life. This is useful information that should be considered in the public policies of maternal leave or benefit to avoid reproductive problems in our society.

The information of this paper has not been submitted for publication elsewhere, and there is no conflict interest

Sincerely yours


Jonathan Martínez
PhD student at the Pharmaceutical and Chemistry Faculty
University of Chile
56-02-9782981